Hemostasis
The Hemostasis test is designed to detect polymorphisms of genes associated with the risk of dyscrasia (bleeding, thrombosis).
Hemostasis
Hemostasis is a biological system in the human body that maintains the stability of the blood state; specifically, it helps preserve its liquid form while simultaneously preventing and stopping bleeding. This process plays a key role in sustaining normal blood circulation, delivering oxygen and nutrients to all organs.
The blood coagulation system functions to prevent dangerous blood loss and the formation of thrombosis. Disruptions in this process can have serious consequences, including fatal outcomes.
Hemostatic gene mutations or polymorphisms are persistent modifications in DNA regions responsible for blood coagulation processes. Such polymorphisms can cause hereditary predispositions to spontaneous bleeding, thrombophilia, pregnancy complications, and cardiovascular events, including stroke and heart attack.
Genes in which polymorphisms occur:
- F2 (prothrombin, coagulation factor II, 20210 G>A);
- F5 (coagulation factor V Leiden, 1691 G>A);
- F7 (coagulation factor VII, 10976 G>A);
- F13 (coagulation factor XIII G>T);
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FGB (fibrinogen beta chain, coagulation factor I, -455 G>A);
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ITGA2 (glycoprotein Ia, VLA-2 receptor 807 C>T);
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ITGB3 (integrin beta 3, platelet factor receptor 1565 T>C);
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SERPINE1 (plasminogen activator inhibitor type I, - 675 5G>4G).
Indications
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Pregnancy -
Family history of thrombotic/bleeding disorders -
Persistent cardiac arrythmias -
Tissue injuries accompanied by external or internal bleeding -
Stroke, myocardial infarction, or pre-infarction condition -
Liver pathology/Hepatic disease -
Detection of hypercoagulability or hypocoagulability
Hemostasis
The Hemostasis test is designed to detect polymorphisms of genes associated with the risk of dyscrasia (bleeding, thrombosis): F2 (prothrombin, coagulation factor II, 20210 G>A); F5 (coagulation factor V Leiden, 1691 G>A); F7 (coagulation factor VII, 10976 G>A); F13 (coagulation factor XIII G>T); FGB (fibrinogen beta chain, coagulation factor I, -455 G>A); ITGA2 (glycoprotein Ia, VLA-2 receptor 807 C>T); ITGB3 (integrin beta 3, platelet factor receptor 1565 T>C); SERPINE1 (plasminogen activator inhibitor type I, - 675 5G>4G) by real-time PCR in human biological material.
Biomaterial: whole peripheral blood, dry blood spots, buccal epithelium.
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Please note that the specialists of the DNA Technology company provide consultations exclusively to medical specialists on the application and research features. Requests related to the appointment, delivery, or interpretation of tests are not considered. For relevant information, we recommend contacting the laboratory directly.