HBV
A test for PCR-based qualitative detection of hepatitis B virus (HBV) DNA in blood plasma samples.
Category «Blood-borne infections»
HBV
Hepatitis B virus (HBV) is a DNA-containing virus belonging to the family Hepadnaviridae. HBV is one of the main pathogens causing acute and chronic liver disease, including cirrhosis and hepatocellular carcinoma.
Hepatitis B virus is transmitted by parenteral, vertical, and sexual routes. Parenteral transmission involves contact with infected blood and bodily fluids, which can occur through blood transfusion, use of non-sterile needles and instruments, and contact with damaged skin and mucous membranes. Sexual transmission occurs through contact with infected bodily fluids such as ejaculate or vaginal secretions. Vertical transmission occurs from mother to child during childbirth.
The main infection mechanism is the virus entry into hepatocytes, where it integrates into the host cell genome, which can lead to chronicization of the inflammatory process and the development of complications.
The acute form of hepatitis B is usually accompanied by activation of T-cells, production of cytokines and neutralizing antibodies, which contributes to virus elimination. In 10% of cases, hepatitis progresses from acute to its chronic form.
Patients with suspected acute hepatitis B infection are advised to do a PCR-based blood test for HBV DNA as a criterion for early diagnosis as well as to establish the viral load. HBV DNA becomes detectable in blood on average one month after infection and 10-20 days before the appearance of HBsAg. In addition, qualitative testing for HBV DNA is performed to assess virological response to treatment with nucleoside/nucleotide analogs.
Indications for testing
-
Confirmation of an ongoing HBV infection -
Monitoring antiviral therapy effectiveness -
Liver diseases of unspecified etiology -
Diagnosis of HBV infection in newborns from infected mothers -
Acquired immune deficiency -
Use of immunosuppressive therapy
HBV
The HBV REAL-TIME PCR Kit is intended for qualitative detection of hepatitis B virus DNA in human biological material by real-time PCR.
The HBV REAL-TIME PCR Kit can be used in research practice.
Sample:Blood plasma, blood serum.
READ MORE
HBV QUANTITATIVE
The HBV Quantitative REAL-TIME PCR Kit is intended for quantitative detection of hepatitis B virus DNA in human biological material by real-time PCR.
The HBV Quantitative REAL-TIME PCR Kit can be used in research practice.
Sample:Blood plasma, blood serum.
READ MORE
Ask questions
Please note that the specialists of the DNA Technology company provide consultations exclusively to medical specialists on the application and research features. Requests related to the appointment, delivery, or interpretation of tests are not considered. For relevant information, we recommend contacting the laboratory directly.