Molecular diagnostics for obstetrician-gynecologists
PCR diagnostics in obstetrician-gynecologists' practice: studying microbiota composition and urogenital tract infections
PCR diagnostics in obstetrician-gynecologists' practice: studying microbiota composition and urogenital tract infections
Due to the high sensitivity and specificity of PCR-based diagnostics, medical professionals can timely and accurately detect various urogenital tract infections (UTIs), as well as determine the ratio between normal and opportunistic microbiota.
PCR-based methods make it possible to determine the presence and quantities of specific microorganism types, as well as to identify disturbances in the balance of UGT microbiota. This enables obstetrician-gynecologist to prescribe adequate treatment aimed at restoring normal microbiota.
PCR diagnostics allows for rapid and accurate identification of the infectious agent, which is especially important for timely initiation of treatment and prevention of potential complications. The most common pathogens causing UGT infections include Mycoplasma genitalium, Trichomonas vaginalis, Neisseria gonorrhoeae, Chlamydia trachomatis.
In prenatal screening, PCR testing enables doctors to perform non-invasive analysis of fetal DNA using only a blood sample from the mother starting from 10 weeks of pregnancy. The test is safe for the course of pregnancy. PCR can be used to determine the rhesus factor of the fetus and prevent the development of Rh incompatibility, as well as for sex determination, which is necessary for identifying gender-linked diseases in prospective parents and prescribing pregnant women with hormone therapy. With the help of NGS methods it is possible to carry out non-invasive screening for aneuploidy and other chromosomal anomalies. Invasive confirmation of the diagnosis can be done using fragment analysis.
PCR is also an accessible method that is effectively used to analyze genetic polymorphisms. This method allows to identify gene polymorphisms associated with folate cycle disorders. Based on these data, the doctor can assess individual risks of each patient and take appropriate actions to prevent folate deficiency, which is crucial for maintaining pregnancy. Testing for gene polymorphisms related to blood coagulation system allows to assess the risk of venous thromboembolic complications during pregnancy.
Due to the high sensitivity and specificity of PCR-based diagnostics, medical professionals can timely and accurately detect various urogenital tract infections (UTIs), as well as determine the ratio between normal and opportunistic microbiota.
Urogenital tract (UGT) microbiota
The balance of microorganisms in women's urogenital tract is of paramount importance for female reproductive health. Disruptions of microbiota can trigger the development of conditions such as bacterial vaginosis, aerobic vaginitis and others.PCR-based methods make it possible to determine the presence and quantities of specific microorganism types, as well as to identify disturbances in the balance of UGT microbiota. This enables obstetrician-gynecologist to prescribe adequate treatment aimed at restoring normal microbiota.
Sexually transmitted infections (STIs)
Sexually transmitted infections can have serious consequences for women's reproductive health, including chronic pelvic pain and infertility.PCR diagnostics allows for rapid and accurate identification of the infectious agent, which is especially important for timely initiation of treatment and prevention of potential complications. The most common pathogens causing UGT infections include Mycoplasma genitalium, Trichomonas vaginalis, Neisseria gonorrhoeae, Chlamydia trachomatis.
Human papillomavirus infection
Human papillomavirus (HPV) is the main etiological factor of cervical cancer. The main mode of transmission of HPV is sexual, and most people become infected with HPV soon after becoming sexually active. PCR testing is included in the WHO recommendations as the preferred screening test for cervical cancer prevention.Genetic testing for pregnancy planning and management
PCR testing of prospective parents at pregnancy planning stage allows to detect asymptomatic carriage of mutations that may manifest in children, which is especially important in cases of family history of hereditary diseases.In prenatal screening, PCR testing enables doctors to perform non-invasive analysis of fetal DNA using only a blood sample from the mother starting from 10 weeks of pregnancy. The test is safe for the course of pregnancy. PCR can be used to determine the rhesus factor of the fetus and prevent the development of Rh incompatibility, as well as for sex determination, which is necessary for identifying gender-linked diseases in prospective parents and prescribing pregnant women with hormone therapy. With the help of NGS methods it is possible to carry out non-invasive screening for aneuploidy and other chromosomal anomalies. Invasive confirmation of the diagnosis can be done using fragment analysis.
PCR is also an accessible method that is effectively used to analyze genetic polymorphisms. This method allows to identify gene polymorphisms associated with folate cycle disorders. Based on these data, the doctor can assess individual risks of each patient and take appropriate actions to prevent folate deficiency, which is crucial for maintaining pregnancy. Testing for gene polymorphisms related to blood coagulation system allows to assess the risk of venous thromboembolic complications during pregnancy.
Our research
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Fungal infectionsThe PCR study makes it possible to identify the causative agent of the infection with precision to the type in the shortest possible time for the correct selection of an antimycotic drug.
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GeneticsPCR diagnostics opens up wide possibilities for identifying genetic mutations that play a crucial role in the development of various diseases. This allows not only to diagnose and prevent the development of diseases at an early stage, but also to provide an individual approach to treatment and the choice of drug therapy.
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Herpesvirus infectionsFast and accurate PCR diagnostics of the main herpes viruses can detect infection at an early stage of the disease.
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Microbiota researchA comprehensive PCR study makes it possible to determine the quantitative and qualitative composition of the microbiota of the urogenital tract of women in order to select the optimal therapy.
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Papillomavirus infectionThe PCR study allows for the typing and quantification of specific types of virus, which is widely used for the prevention and diagnosis of HPV-associated cancers.
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Prenatal diagnosisCarrying out a molecular genetic study of fetal DNA from the mother's blood allows for genetic analysis without invasive intervention, which reduces the risks to the health of both mother and child.
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Urogenital infectionsPCR diagnostics allows you to quickly and accurately identify the causative agent of infection, which is especially important for timely initiation of treatment and prevention of possible complications.
- TNC Multiplex
- UMC Multiplex
- NTCM Multiplex
- Gardnerella vaginalis
- Neisseria gonorrhoeae
- Mycoplasma genitalium
- Mycoplasma hominis
- Ureaplasma urealyticum – Ureaplasma parvum
- Trichomonas vaginalis
- Chlamydia trachomatis
- C.trachomatis/T.vaginalis Multiplex
- C.trachomatis/N.gonorrhoeae Multiplex
- T.vaginalis/N.gonorrhoeae Multiplex
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