PCR for genetic testing

Genetic tests for pregnancy planning

PCR testing for prospective parents allows to detect asymptomatic carriage of mutations that may manifest in children. This is important for pregnancy planning and healthy childbirth, especially in cases of family history of hereditary diseases. PCR testing can also be used to diagnose one of the factors of male infertility – deletions in the azoospermia factor (AZF) locus.

Genetic testing in prenatal screening

Performing non-invasive fetal DNA tests using mother’s blood is possible starting from 10 weeks of pregnancy. The testing process is safe for the course of pregnancy. PCR testing for fetal rhesus factor helps prevent the development of rhesus incompatibility. Early sex determination before childbirth is necessary for detecting gender-linked diseases in future parents, as well as for prescribing hormone therapy to pregnant women. Non-invasive screening for aneuploidy and other chromosomal abnormalities is possible using NGS method. Fragment analysis allows to confirm the diagnosis invasively.

Detecting genetic polymorphisms

PCR is an accessible method that is effective for analyzing genetic polymorphisms. PCR studies help understand individual predisposition to certain conditions, including cardiovascular, oncological and metabolic diseases. Based on these data, the doctor can assess each individual patient’s risk and take appropriate actions for disease treatment and prevention.

Pharmacogenetics

PCR is widely used to identify genetic polymorphisms associated with drug metabolism. PCR diagnostics enables the identification of genetic polymorphisms that may affect metabolism of drugs such as warfarin and clopidogrel. This information helps establish the optimal dosage of the drug to be prescribed to a specific patient, thus minimizing the risk of bleeding and thrombosis.

Oncogenetics

PCR diagnostics can also be used in oncogenetics both to determine the risk of hereditary cancers as well as for targeted therapy.
Timely detection of mutations in BRCA1 and BRCA2 genes is instrumental to assessing the risk of developing malignant neoplasms in the breast and ovaries and to creating a tailored treatment strategy. The determination of the mutation spectrum in the EGFR gene is important for prescribing targeted therapy with tyrosine kinase inhibitors to patients with non-small-cell lung cancer.

Our research

• Genetics

  PCR studies to detect genetic mutations.
  
  

  • Folate Metabolism
  • Hemostasis
  • Lactose Intolerance
  • Calcium Metabolism
  • BRCA mutations
  • IL28B (Immunogenetics)
  • EGFR
  • Warfarin Pharmacogenetics
  • Clopidogrel Pharmacogenetics

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Please note that the specialists of the DNA Technology company provide consultations exclusively to medical specialists on the application and research features. Requests related to the appointment, delivery, or interpretation of tests are not considered. For relevant information, we recommend contacting the laboratory directly.

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