Trichomonas vaginalis
The test is designed for Trichomonas vaginalis DNA detection in human biological material by real-time PCR.
Category «Urogenital infections»
About Trichomonas vaginalis
Trichomonas vaginalis is a single-celled anaerobic microorganism belonging to the class Flagellata. It is the causative agent of trichomoniasis, one of the most common sexually transmitted infections. T. vaginalis attaches to the epithelial cells of the urogenital tract using flagella and specific proteins – adhesins. Trichomonads produce cytotoxic chemicals, such as the cell-detaching factor and N-nitrosamines, which stimulate the development of epithelial atypia and dysplasia.
An important aspect of the pathobiology of urogenital trichomoniasis is the complex interrelationship between T. vaginalis and intracellular symbiotic microorganisms, particularly M. hominis, which accounts for the high variability of clinical manifestations and complications of this infection. The biological link between T. vaginalis and M. hominis significantly influences certain aspects of the pathogenesis of infectious processes caused by both microorganisms. Essentially, M. hominis gains protection from the effects of antibiotics and the host’s immune response due to its intracellular localization within trichomonad cells, while T. vaginalis, in turn, enhances its cytopathic activity, damage to host cells, and activates phagocytosis and the pro-inflammatory response.
In 20–40% of cases, subjectively asymptomatic urogenital trichomoniasis is observed, which complicates timely diagnosis, delays the initiation of treatment in the early stages of the disease, and leads to the development of complications and further spread of the infection.
Primary symptoms of the infection
- In women, urogenital trichomoniasis primarily presents with vulvovaginitis, cervicitis, and less commonly urethritis. It may be accompanied by symptoms such as genital discharge with an unpleasant odor, itching, burning, pain during urination and sexual intercourse. In cases of ascending infection, pelvic inflammatory disease (PID) may develop.
- In men, the epithelium of the urethral mucosa is initially infected, after which trichomonads may spread to the tissues of the prostate gland and seminal vesicles. The most common symptoms include urethral discharge and pain during urination.
Urogenital trichomoniasis is associated with complications such as ectopic pregnancy, preterm birth, low birth weight, and infertility in individuals of both sexes.
PCR testing enables etiological and differential diagnosis within a short timeframe, even in asymptomatic cases, and allows for timely causal therapy.
Indications
-
Signs of urogenital tract inflammatory process -
Redness, itching, swelling -
Unpleasant odor -
Infertility -
Preconception examination, including preparation for IVF -
Assessment of therapy efficacy and treatment outcomes -
Pelvic surgery -
STIs in sexual partner
Trichomonas vaginalis
The Trichomonas vaginalis test is designed for Trichomonas vaginalis DNA detection in human biological material by real-time PCR.
Biomaterial: epithelial cell swabs from urogenital tract, urine, prostate fluid, ejaculate.
Find out more
Information
Ask questions
Please note that the specialists of the DNA Technology company provide consultations exclusively to medical specialists on the application and research features. Requests related to the appointment, delivery, or interpretation of tests are not considered. For relevant information, we recommend contacting the laboratory directly.