MycosoScreen
A test for detecting and typing fungal pathogens of the genuses Candida, Malassezia, Saccharomyces and Debaryomyces.
Mycoses
Mycoses are infections caused by pathogenic and opportunistic fungi that can affect the skin, nails, mucous membranes and internal organs. Based on clinical picture, mycoses can be superficial or invasive.
Superficial mycoses affect the skin, nails, and mucous membranes. These infections are often caused by fungi of the genus Candida and Malassezia. Superficial mycoses include: vulvovaginal candidiasis (VVC), which causes complications such as urethritis, cystitis, PIDs, obstetric pathology, fetal infection, postpartum endometritis and salpingitis; oropharyngeal candidiasis; and dermatoses associated with yeast fungi.
Invasive mycoses occur when pathogens enter the blood and lymph circulation and affect internal organs. Depending on the presence of infection in the blood and the damage to internal organs, there can either be fungemia without internal organ damage, organ damage without fungemia, or a combination of fungemia and fungal organ damage. The risk group developing invasive mycoses includes patients in ICU, patients with immune deficiencies, cancer patients, patients after organ transplants, premature newborns with low body weight.
Accurate and timely fungal typing and quantification is an important step in reaching a diagnosis. Depending on the species and quantity of the pathogen, the treatment strategies for patients with invasive mycoses may differ significantly.
MycosoScreen detection kit is used for detecting and typing the following fungal pathogens:
- Meyerozyma guilliermondii (C. guilliermondii) is a causative agent of invasive infections in patients with oncopathology, a history of cardiovascular or intra-abdominal surgery; may cause catheter-associated candidemia and candida osteomyelitis.
- Candida albicans is known as the most widespread causative agent of candidiasis, including superficial skin and mucosal infections.
- Pichia kudriavzevii (C. krusei) is resistant to many antifungal drugs and often causes invasive infections with a high mortality rate in surgical patients and patients with neutropenia.
- Saccharomyces cerevisiaeis normally present on oral and vaginal mucosa, in feces and sputum, but may cause opportunistic infections in immunocompromised patients.
- Candida auris can cause nosocomial candidiasis and invasive candidal infections with a high mortality rate of up to 60%. It has multiple resistance to antifungal drugs and disinfectants, and is characterized by its ability to colonize a wide range of surfaces and form persistent biofilms.
- Candida tropicalis is the causative agent of catheter-associated candidemia and candida osteomyelitis; it is associated with the development of chronic candidiasis of the oral and GI mucosa accompanied by necrosis.
- Clavispora lusitaniae (C. lusitaniae) is the causative agent of vulvovaginal and oropharyngeal candidiasis; can cause invasive infections. Resistant to amphotericin B.
- Debaryomyces hansenii (C. famata) causes catheter-associated infections, may also cause urinary tract infections. Often found in the intestines of patients with Crohn's disease.
- Candida dubliniensis is the causative agent of oropharyngeal candidiasis in HIV-infected and cystic fibrosis patients. May cause vulvovaginal candidiasis and eye infections outside of immunosuppression.
- Candida glabrata is a frequent pathogen of vulvovaginal candidiasis, urinary infections, endocarditis, and meningitis. It is often resistant to fluconazole and causes invasive infections in diabetic patients and the elderly.
- Candida parapsilosis often causes infections in newborns and patients with invasive devices (catheters, including those for parenteral nutrition, intubation tubes, drains).
- Kluyveromyces marxianus (C. kefyr) causes infections in patients with compromised immune systems.
- Malassezia spp. are representatives of the normal human skin microflora and include species that can cause superficial skin infections or invasive lesions under certain conditions. They are capable of biofilm formation, which contributes to the development of antimycotic resistance.
- Malassezia furfur is the causative agent of superficial skin infections such as seborrheic dermatitis and tinea versicolor. In immunocompromised patients, it can cause pneumonia and catheter-associated fungemia.
Indications for testing
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Chronic dermatologic conditions -
Suspected candidiasis -
Wounds, burns, bedsores and other violations of skin integrity -
Treatment with broad-spectrum antibiotics -
Presence of invasive devices (catheters, drains, intubation tubes) -
Immunodeficiency disorders -
Evaluation of treatment effectiveness -
Testing for yeast cultures
MycosoScreen
MycosoScreen REAL-TIME PCR Detection Kit is intended for detection and typing of pathogens causing mycoses from genus Candida, Malassezia, Saccharomyces and Debaryomyces in samples from human biological material by Real-Time PCR method.
Sample: Blood, phlegm, urine, swabs/scrapes from respiratory tract, gastrointestinal and urogenital tracts, faeces, bioptates, catheter and endotracheal tube washings, and fungal cultures.
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Please note that the specialists of the DNA Technology company provide consultations exclusively to medical specialists on the application and research features. Requests related to the appointment, delivery, or interpretation of tests are not considered. For relevant information, we recommend contacting the laboratory directly.