Gardnerella vaginalis
The test is designed for Gardnerella vaginalis DNA detection in human biological material by real-time PCR.
Category «Urogenital infections»
About Gardnerella vaginalis
Gardnerella vaginalis is an opportunistic pathogen referring to anaerobic bacteria which is one of the main bacterial vaginosis pathogens. G. vaginalis can synthesize sialidase, which modifies glycoproteins of vaginal mucosa and provides the ability to attach to epithelial cells of vaginal mucosa. Adhesive activity of G. vaginalis results in biofilm production, which contributes to colonization by other opportunistic and pathogenic microorganisms, improves resistance of the bacteria to antibiotics, lactic acid and hydrogen peroxide produced by lactobacilli.
The primary mode of transmission for Gardnerella vaginalis is sexual contact. The incubation period following initial infection with Gardnerella vaginalis is not precisely defined, as this bacterium can be present asymptomatically in the vaginal biotope for extended periods. Infection can develop due to alterations in the vaginal microbiota, characterized by a decline in protective lactobacilli and conditions favorable for the growth of G. vaginalis. Lactobacilli, which normally suppress the growth of G. vaginalis, are replaced by opportunistic bacteria, including Gardnerella. Disruption of the vaginal flora can occur under the influence of various factors:
- Antibiotic use
- Hormonal changes
- Immunodeficiency conditions
- Surgical interventions
- Poor intimate hygiene
Primary symptoms of bacterial vaginosis caused by G. vaginalis
- Change in discharge nature: becomes profuse, grayish or white in color, with an unpleasant “fish-like” odor
- Burning or itching in the vulvar area
- Discomfort or pain during sexual intercourse
- Itching, burning, or pain during urination (dysuria)
Bacterial vaginosis is associated with an increased risk of acquiring STIs and pregnancy complications, including miscarriage, preterm birth, and the development of postpartum endometritis. Beyond vaginosis, G. vaginalis can be the cause of other infectious diseases. For instance, there is a link between this bacterium and pelvic inflammatory disease. In rare cases, Gardnerella vaginalis can cause urological infections in men, such as urethritis and prostatitis, particularly in the presence of contributing factors.
Indications
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Clinical and/or laboratory signs of urogenital tract inflammatory process
Redness, itching, swelling
Unpleasant odor
Infertility
Preconception examination, including preparation for IVF
Assessment of therapy efficacy and treatment outcomes
Pelvic surgery
Gardnerella vaginalis
The Gardnerella vaginalis test is designed for Gardnerella vaginalis DNA detection in human biological material by real-time PCR.
Biomaterial: epithelial cell swabs from urogenital tract, urine, prostate fluid, ejaculate.
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Please note that the specialists of the DNA Technology company provide consultations exclusively to medical specialists on the application and research features. Requests related to the appointment, delivery, or interpretation of tests are not considered. For relevant information, we recommend contacting the laboratory directly.